Price range: $268.00 through $328.00
Background:
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1, 4, 5-trisphosphate to Ins(1, 3, 4, 5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | InsP 3-kinase B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 100kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from InsP 3-kinase B . at AA range: 130-210 |
| Specificity | InsP 3-kinase B Polyclonal Antibody detects endogenous levels of InsP 3-kinase B protein. |
| Gene Name | ITPKB |
| Protein Name | Inositol-trisphosphate 3-kinase B |
| Other Name | ITPKB; / Inositol-trisphosphate 3-kinase B; / Inositol 1; / 4,5-trisphosphate 3-kinase B; / IP3 3-kinase B; / IP3K B; / InsP 3-kinase B |
| Species | Human |
| Gene ID | 3707 |
| Uniprot | P27987, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 54260 |
| Uniprot.2 | P42335 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cytoplasm . Endoplasmic reticulum . |
| Tissue Expression | Brain,Cerebellum,Colon,Hippocampus,Platelet,Skin, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Calcium signaling pathway; / >>Phosphatidylinositol signaling system |
| Function | Catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.,similarity:Belongs to the inositol phosphokinase (IPK) family., |
