Product details
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IRF8 rabbit pAb
Ucallm_WP6322-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | IRF8 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 47kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human IRF8 |
| Specificity | This antibody detects endogenous levels of IRF8 at Human, Mouse |
| Gene Name | IRF8 ICSBP1 |
| Protein Name | Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) |
| Other Name | |
| Species | Human |
| Gene ID | 3394 |
| Uniprot | Q02556, |
| Species.1 | Mouse |
| Gene ID.1 | 15900 |
| Uniprot.1 | P23611 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. . |
| Tissue Expression | Predominantly expressed in lymphoid tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) . Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells . |
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