JMJD6 [N-term] mouse mAb
Ucallm_WM0555-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | PSR |
| Reactivity | Human |
| Applications | WB, ICC |
| MW(Calculated) | |
| MW(Observed) | 62kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 12D9 |
| Immunogen | Purified recombinant human JMJD6(N-terminus) fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of JMJD6(N-terminus) and does not cross-react with related proteins. |
| Gene Name | jmjd6 |
| Protein Name | |
| Other Name | Apoptotic cell clearance receptor; / Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; / Histone arginine demethylase JMJD6; / JmjC domain-containing protein 6; / JMJD 6; / JMJD6; / JMJD6_HUMAN; / Jumonji domain containing 6; / Jumonji domain-containing protein 6; / KIAA0585; / Lysyl-hydroxylase JMJD6; / Peptide-lysine 5-dioxygenase JMJD6; / Phosphatidylserine receptor; / Protein PTDSR; / PSR; / PTDSR 1; / PTDSR; / PTDSR1. |
| Species | Human |
| Gene ID | 23210 |
| Uniprot | Q6NYC1 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleoplasm . Nucleus, nucleolus . Cytoplasm . Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. . |
| Tissue Expression | Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Caution:Was initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition of phosphatidylserine, a specific marker only present at the surface of apoptotic cells. Phosphatidylserine receptor probably participates in apoptotic cell phagocytosis. This protein was identified using phage display expressing mAb 217, an antibody that specifically recognizes phosphatidylserine receptor. However, its nuclear localization and the fact that mAb 217 antibody still recognizes the phosphatidylserine receptor in mice lacking JMJD6, strongly suggest that it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal.,Domain:The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.,Function:Arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me). Required for differentiation of multiple organs during embryogenesis. Probably acts as a key regulator of hematopoietic differentiation. Seems to be necessary for the regulation of macrophage cytokine responses.,induction:Up-regulated upon cytokine treatment, but not upon TNF-alpha treatment.,similarity:Belongs to the PTDSR family.,similarity:Contains 1 JmjC domain.,tissue specificity:Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells., |
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