JPH2 Polyclonal Antibody
Ucallm_WP2855-50
Price range: $268.00 through $328.00
Product details
Background:
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | JPH2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 76kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 611-660 |
| Specificity | JPH2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | JPH2 JP2 |
| Protein Name | Junctophilin-2 (JP-2) (Junctophilin type 2) |
| Other Name | |
| Species | Human |
| Gene ID | 57158 |
| Uniprot | Q9BR39, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9ET78, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q2PS20 |
| Cellular Localization | [Junctophilin-2]: Cell membrane; Peripheral membrane protein . Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein . Endoplasmic reticulum membrane; Single-pass type IV membrane protein . The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. .; [Junctophilin-2 N-terminal fragment]: Nucleus . Accumulates in the nucleus of stressed hearts. . |
| Tissue Expression | Specifically expressed in skeletal muscle and heart. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.,Function:Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development.,similarity:Belongs to the junctophilin family.,similarity:Contains 8 MORN repeats.,subcellular location:Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.,tissue specificity:Specifically expressed in skeletal muscle and heart., |
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