Price range: $268.00 through $328.00
Background:
Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | KALIG-1 |
| Reactivity | Human |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 76kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KAL1. AA range:151-200 |
| Specificity | KALIG-1 Polyclonal Antibody detects endogenous levels of KALIG-1 protein. |
| Gene Name | KAL1 |
| Protein Name | Anosmin-1 |
| Other Name | KAL1; / ADMLX; / KAL; / KALIG1; / Anosmin-1; / Adhesion molecule-like X-linked; / Kallmann syndrome protein |
| Species | Human |
| Gene ID | 3730 |
| Uniprot | P23352 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein . Secreted . Proteolytic cleavage may release it from the cell surface into the extracellular space. |
| Tissue Expression | Expressed in the cerebellum (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.,Function:May be an adhesion-like molecule with anti-protease activity.,PTM:N-glycosylated.,similarity:Contains 1 WAP domain.,similarity:Contains 4 fibronectin type-III domains., |
