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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/KCNC3 rabbit pAb
SKU: WP3869 Categories: ,

KCNC3 rabbit pAb

Ucallm_WP3869-50

Price range: $268.00 through $328.00

SKU: WP3869-100
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Product details

Background:

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014],

Specifications

Size50μL/100μL
TargetKCNC3
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)83kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human KCNC3 AA range: 303-353
SpecificityThis antibody detects endogenous levels of KCNC3 at Human/Mouse/Rat
Gene NameKCNC3
Protein NameKCNC3
Other Name
SpeciesHuman
Gene ID3748
UniprotQ14003,
Species.1Mouse
Gene ID.1
Uniprot.1Q63959,
Species.2Rat
Gene ID.2
Uniprot.2Q01956
Cellular LocalizationCell membrane; Multi-pass membrane protein . Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein . Perikaryon . Cell projection, axon . Cell projection, dendrite . Cell projection, dendritic spine membrane; Multi-pass membrane protein . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484). .
Tissue Expression
Signaling_pathwayHuman Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia
Research Areas>>Spinocerebellar ataxia
FunctionDisease:Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.,Domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,Function:This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Heterotetramer of potassium channel proteins.,
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