KCNC3 rabbit pAb
Ucallm_WP3869-50
Price range: $268.00 through $328.00
Product details
Background:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014],
Specifications
| Size | 50μL/100μL |
| Target | KCNC3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 83kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KCNC3 AA range: 303-353 |
| Specificity | This antibody detects endogenous levels of KCNC3 at Human/Mouse/Rat |
| Gene Name | KCNC3 |
| Protein Name | KCNC3 |
| Other Name | |
| Species | Human |
| Gene ID | 3748 |
| Uniprot | Q14003, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q63959, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q01956 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein . Perikaryon . Cell projection, axon . Cell projection, dendrite . Cell projection, dendritic spine membrane; Multi-pass membrane protein . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484). . |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia |
| Research Areas | >>Spinocerebellar ataxia |
| Function | Disease:Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.,Domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,Function:This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Heterotetramer of potassium channel proteins., |
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