KCNE4 Polyclonal Antibody
Ucallm_WP1506-50
Price range: $268.00 through $328.00
Product details
Background:
potassium voltage-gated channel subfamily E regulatory subunit 4(KCNE4) Homo sapiens Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | KCNE4 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 18kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Specificity | KCNE4 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | KCNE4 |
| Protein Name | Potassium voltage-gated channel subfamily E member 4 (MinK-related peptide 3) (Minimum potassium ion channel-related peptide 3) (Potassium channel subunit beta MiRP3) |
| Other Name | |
| Species | Human |
| Gene ID | 23704 |
| Uniprot | Q8WWG9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9WTW3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass membrane protein . |
| Tissue Expression | Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex.,Function:Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.,similarity:Belongs to the potassium channel KCNE family.,subunit:Associates with KCNQ1/KVLQT1.,tissue specificity:Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart., |
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