KIF5C rabbit pAb
Ucallm_WP3654-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015],
Specifications
| Size | 50μL/100μL |
| Target | KIF5C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KIF5C AA range: 119-169 |
| Specificity | This antibody detects endogenous levels of KIF5C at Human/Mouse/Rat |
| Gene Name | KIF5C KIAA0531 NKHC2 |
| Protein Name | KIF5C |
| Other Name | Kinesin heavy chain isoform 5C; / Kinesin heavy chain neuron-specific 2 |
| Species | Human |
| Gene ID | 3800 |
| Uniprot | O60282, |
| Species.1 | Mouse |
| Gene ID.1 | 16574 |
| Uniprot.1 | P28738, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P56536 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, dendrite . Abundant in distal regions of dendrites. . |
| Tissue Expression | Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Endocytosis; / >>Dopaminergic synapse; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Salmonella infection; / >>Non-small cell lung cancer |
| Function | Domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,Function:Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3.,tissue specificity:Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary., |
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