Name: KRT85 Polyclonal Antibody
SKU: WP2197
Price: 268 USD
Availability: InStock

KRT85 Polyclonal Antibody

Ucallm_WP2197-50

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WP2197-100

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Product details

Background:

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	KRT85
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	55kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein AA range: 450-500
Specificity	KRT85 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	KRT85 KRTHB5
Protein Name	Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)
Other Name
Species	Human
Gene ID	3891
Uniprot	P78386,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9Z2T6
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	extracellular space,intermediate filament,keratin filament,
Tissue Expression	Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.
Signaling_pathway
Research Areas
Function	Caution:Maps to a duplicated region on chromosome 12.,Disease:Defects in KRT85 are the cause of ectodermal dysplasia pure hair-nail type (EDPHN) [MIM:602032]. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDPHN is characterized by complete alopecia, hypotricosis and nail dystrophy in all digits. There is no evidence of any other abnormality. Inheritance can be autosomal dominant or recessive.,miscellaneous:There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.,

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KRT85 Polyclonal Antibody

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KRT85 Polyclonal Antibody

Product details

Specifications

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