LARGE rabbit pAb
Ucallm_WP8563-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | LARGE1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 83kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LARGE |
| Specificity | This antibody detects endogenous levels of LARGE at Human, Mouse |
| Gene Name | LARGE KIAA0609 LARGE1 |
| Protein Name | Glycosyltransferase-like protein LARGE1 (Acetylglucosaminyltransferase-like 1A) |
| Other Name | |
| Species | Human |
| Gene ID | 9215 |
| Uniprot | O95461, |
| Species.1 | Mouse |
| Gene ID.1 | 16795 |
| Uniprot.1 | Q9Z1M7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein . |
| Tissue Expression | Ubiquitous. Highest expression in heart, brain and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity . Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide . Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer . Plays a key role in skeletal muscle function and regeneration (By similarity). |
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