Name: LASP-1 Polyclonal Antibody
SKU: WP15307
Price: 268 USD
Availability: InStock

LASP-1 Polyclonal Antibody

Ucallm_WP15307-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP15307-100

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Product details

Background:

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012],

Specifications

Size	50μL/100μL
Target	LASP1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC
MW(Calculated)
MW(Observed)	28kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human LASP1. AA range:51-100
Specificity	LASP-1 Polyclonal Antibody detects endogenous levels of LASP-1 protein.
Gene Name	LASP1 MLN50
Protein Name	LIM and SH3 domain protein 1
Other Name	LASP1; / MLN50; / LIM and SH3 domain protein 1; / LASP-1; / Metastatic lymph node gene 50 protein; / MLN 50
Species	Human
Gene ID	3927
Uniprot	Q14847,
Species.1	Mouse
Gene ID.1	16796
Uniprot.1	Q61792,
Species.2	Rat
Gene ID.2	29278
Uniprot.2	Q99MZ8
Cellular Localization	Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Associated with the F-actin rich cortical cytoskeleton. .
Tissue Expression	Epithelium,Liver,Mammary carcinoma,Platelet,Skin,T-cell,
Signaling_pathway
Research Areas
Function	Function:Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.,PTM:Phosphorylated.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 nebulin repeats.,subcellular location:Associated with the F-actin rich cortical cytoskeleton.,subunit:Interacts with F-actin.,

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LASP-1 Polyclonal Antibody

Product details

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LASP-1 Polyclonal Antibody

Product details

Specifications

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