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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/LDHA Polyclonal Antibody
SKU: WP3400 Categories: ,

LDHA Polyclonal Antibody

Ucallm_WP3400-50

Price range: $268.00 through $328.00

SKU: WP3400-100
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Product details

Background:

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],

Specifications

Size50μL/100μL
TargetLDHA
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)36kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein. AA range 51-71
SpecificityLDHA Polyclonal Antibody detects endogenous levels of protein.
Gene NameLDHA PIG19
Protein NameL-lactate dehydrogenase A chain (LDH-A) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)
Other Name
SpeciesHuman
Gene ID3939
UniprotP00338,
Species.1Mouse
Gene ID.1
Uniprot.1P06151,
Species.2Rat
Gene ID.2
Uniprot.2P04642
Cellular LocalizationCytoplasm.
Tissue ExpressionPredominantly expressed in anaerobic tissues such as skeletal muscle and liver.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Glucagon signaling pathway;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas>>Glycolysis / Gluconeogenesis; / >>Cysteine and methionine metabolism; / >>Pyruvate metabolism; / >>Propanoate metabolism; / >>Metabolic pathways; / >>HIF-1 signaling pathway; / >>Glucagon signaling pathway; / >>Central carbon metabolism in cancer
FunctionCatalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer.,
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