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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/MLK3 Polyclonal Antibody
SKU: WP13192 Categories: ,

MLK3 Polyclonal Antibody

Ucallm_WP13192-50

Price range: $268.00 through $328.00

SKU: WP13192-100
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Product details

Background:

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetMLK3
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)93kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human MLK3. AA range:640-689
SpecificityMLK3 Polyclonal Antibody detects endogenous levels of MLK3 protein.
Gene NameMAP3K11
Protein NameMitogen-activated protein kinase kinase kinase 11
Other NameMAP3K11; / MLK3; / PTK1; / SPRK; / Mitogen-activated protein kinase kinase kinase 11; / Mixed lineage kinase 3; / Src-homology 3 domain-containing proline-rich kinase
SpeciesHuman
Gene ID4296
UniprotQ16584,
Species.1Mouse
Gene ID.126403
Uniprot.1Q80XI6,
Species.2Rat
Gene ID.2309168
Uniprot.2Q66HA1
Cellular LocalizationCytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent.
Tissue ExpressionExpressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> MAPK signaling pathway
Research Areas>>MAPK signaling pathway; / >>Non-alcoholic fatty liver disease
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,Function:Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subcellular location:Location is cell cycle dependent.,subunit:Homodimer; undergoes dimerization during activation.,tissue specificity:Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.,
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Immunohistochemical analysis of paraffin-embedded Rat liver tissue. 1, primary Antibody was diluted at 1:200(4～C,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98～C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).
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