Name: BAAT Polyclonal Antibody
SKU: WP0931
Price: 268 USD
Availability: InStock

BAAT Polyclonal Antibody

Ucallm_WP0931-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP0931-100

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Product details

Background:

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	BAAT
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	45kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	BAAT Polyclonal Antibody detects endogenous levels of protein.
Gene Name	BAAT
Protein Name	Bile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2)
Other Name
Species	Human
Gene ID	570
Uniprot	Q14032,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q91X34,
Species.2	Rat
Gene ID.2
Uniprot.2	Q63276
Cellular Localization	Cytoplasm, cytosol . Peroxisome .
Tissue Expression	Expressed in the gallbladder mucosa and pancreas (PubMed:2037576, PubMed:12810727). Expressed in hepatocytes (at protein level) (PubMed:2037576, PubMed:12810727, PubMed:23415802).
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Peroxisome
Research Areas	>>Primary bile acid biosynthesis; / >>Taurine and hypotaurine metabolism; / >>Biosynthesis of unsaturated fatty acids; / >>Metabolic pathways; / >>Peroxisome; / >>Bile secretion
Function	Catalytic activity:Choloyl-CoA + glycine = CoA + glycocholate.,Catalytic activity:Palmitoyl-CoA + H(2)O = CoA + palmitate.,Disease:Defects in BAAT are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.,Function:Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.,miscellaneous:In humans more than 95% of the biliary bile acids are N-acyl amidates with glycine and taurine. In other mammalian species large differences are observed in the relative amounts of taurine- and glycine-conjugated bile acids formed in bile.,similarity:Belongs to the C/M/P thioester hydrolase family.,subunit:Monomer.,tissue specificity:Expressed in liver, gallbladder mucosa and pancreas.,

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BAAT Polyclonal Antibody

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BAAT Polyclonal Antibody

Product details

Specifications

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