LDHB Polyclonal Antibody
Ucallm_WP3401-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016],
Specifications
| Size | 50μL/100μL |
| Target | LDHB |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein. AA range 65-105 |
| Specificity | LDHB Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LDHB |
| Protein Name | L-lactate dehydrogenase B chain (LDH-B) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) |
| Other Name | |
| Species | Human |
| Gene ID | 3945 |
| Uniprot | P07195, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P16125, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P42123 |
| Cellular Localization | Cytoplasm. Mitochondrion inner membrane; Peripheral membrane protein . |
| Tissue Expression | Predominantly expressed in aerobic tissues such as cardiac muscle. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway |
| Research Areas | >>Glycolysis / Gluconeogenesis; / >>Cysteine and methionine metabolism; / >>Pyruvate metabolism; / >>Propanoate metabolism; / >>Metabolic pathways; / >>HIF-1 signaling pathway; / >>Glucagon signaling pathway; / >>Central carbon metabolism in cancer |
| Function | Catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,Disease:Defects in LDHB are a cause of hereditary LDHB deficiency [MIM:150100]. LDHB deficiency is usually asymptomatic.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer., |
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