Name: LPCAT2 Polyclonal Antibody
SKU: WP13017
Price: 268 USD
Availability: InStock

LPCAT2 Polyclonal Antibody

Ucallm_WP13017-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP13017-100

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Product details

Background:

This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009],

Specifications

Size	50μL/100μL
Target	LPCAT2
Reactivity	Human, Mouse, Rat
Applications	WB, IHC
MW(Calculated)
MW(Observed)	50kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human LPCAT2. AA range:321-370
Specificity	LPCAT2 Polyclonal Antibody detects endogenous levels of LPCAT2 protein.
Gene Name	LPCAT2
Protein Name	Lysophosphatidylcholine acyltransferase 2
Other Name	LPCAT2; / AYTL1; / Lysophosphatidylcholine acyltransferase 2; / LPC acyltransferase 2; / LPCAT-2; / LysoPC acyltransferase 2; / 1-acylglycerophosphocholine O-acyltransferase; / 1-alkylglycerophosphocholine O-acetyltransferase; / Acetyl-CoA:lyso-platelet-ac
Species	Human
Gene ID	54947
Uniprot	Q7L5N7,
Species.1	Mouse
Gene ID.1	270084
Uniprot.1	Q8BYI6,
Species.2	Rat
Gene ID.2
Uniprot.2	P0C1Q3
Cellular Localization	Endoplasmic reticulum membrane; Single-pass type II membrane protein . Golgi apparatus membrane; Single-pass type II membrane protein . Cell membrane; Single-pass type II membrane protein . Lipid droplet .
Tissue Expression	Carcinoma,Fetal kidney,Kidney,
Signaling_pathway
Research Areas	>>Glycerophospholipid metabolism; / >>Ether lipid metabolism; / >>Metabolic pathways
Function	Catalytic activity:Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.,Catalytic activity:Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.,Domain:The HXXXXD motif is essential for acyltransferase activity.,enzyme regulation:Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged.,Function:Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-alkyl-phosphatidylcholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases.,pathway:Lipid metabolism; phospholipid metabolism.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,similarity:Contains 2 EF-hand domains.,