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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/LPP3 rabbit pAb
SKU: WP3800 Categories: ,

LPP3 rabbit pAb

Ucallm_WP3800-50

Price range: $268.00 through $328.00

SKU: WP3800-100
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Product details

Background:

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010],

Specifications

Size50μL/100μL
TargetLPP3
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)34kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human LPP3 AA range: 205-255
SpecificityThis antibody detects endogenous levels of LPP3 at Human/Mouse/Rat
Gene NamePPAP2B LPP3
Protein NameLPP3
Other Name
SpeciesHuman
Gene ID8613
UniprotO14495,
Species.1Mouse
Gene ID.167916
Uniprot.1Q99JY8,
Species.2Rat
Gene ID.2
Uniprot.2P97544
Cellular LocalizationCell membrane; Multi-pass membrane protein . Basolateral cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein . Golgi apparatus membrane; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein . Membrane raft; Multi-pass membrane protein . Cycles between the endoplasmic reticulum and the Golgi. .
Tissue ExpressionUbiquitously expressed (PubMed:9305923, PubMed:12660161). Highly expressed in heart and placenta (PubMed:9305923).
Signaling_pathwayOrganismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
Research Areas>>Glycerolipid metabolism; / >>Glycerophospholipid metabolism; / >>Ether lipid metabolism; / >>Sphingolipid metabolism; / >>Metabolic pathways; / >>Phospholipase D signaling pathway; / >>Fc gamma R-mediated phagocytosis; / >>Fat digestion and absorption; / >>Choline metabolism in cancer
FunctionCatalytic activity:A 3-sn-phosphatidate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.,enzyme regulation:Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.,Function:Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.,induction:By epidermal growth factor (EGF), vascular endothelial growrh factor (VEGF), basic fibroblast growth factor (bFGF) and phorbol myristate acetate (PMA).,PTM:N-glycosylated. Contains high-mannose oligosaccharides.,similarity:Belongs to the PA-phosphatase related phosphoesterase family.,subunit:Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability.,tissue specificity:Ubiquitously expressed. Highly expressed in heart and placenta.,
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