Product details
Background:
LRRC8D rabbit pAb
Ucallm_WP7537-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | LRRC8D |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 94kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LRRC8D |
| Specificity | This antibody detects endogenous levels of LRRC8D at Human, Mouse,Rat |
| Gene Name | LRRC8D LRRC5 UNQ213/PRO239 |
| Protein Name | Leucine-rich repeat-containing protein 8D (Leucine-rich repeat-containing protein 5) |
| Other Name | |
| Species | Human |
| Gene ID | 55144 |
| Uniprot | Q7L1W4, |
| Species.1 | Mouse |
| Gene ID.1 | 231549 |
| Uniprot.1 | Q8BGR2, |
| Species.2 | Rat |
| Gene ID.2 | 305131 |
| Uniprot.2 | Q5U308 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine . Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress . LRRC8A and LRRC8D are required for the uptake of the drug cisplatin . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol . Mediates the import of the antibiotic blasticidin-S into the cell . |
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