Price range: $268.00 through $328.00
Background:
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | LSP1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 37kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LSP1. AA range:104-153 |
| Specificity | LSP1 Polyclonal Antibody detects endogenous levels of LSP1 protein. |
| Gene Name | LSP1 |
| Protein Name | Lymphocyte-specific protein 1 |
| Other Name | LSP1; / WP34; / Lymphocyte-specific protein 1; / 47 kDa actin-binding protein; / 52 kDa phosphoprotein; / pp52; / Lymphocyte-specific antigen WP34 |
| Species | Human |
| Gene ID | 4046 |
| Uniprot | P33241, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P19973 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Tissue Expression | Activated T-lymphocytes. |
| Signaling_pathway | |
| Research Areas | >>C-type lectin receptor signaling pathway; / >>Tuberculosis |
| Function | Function:May play a role in mediating neutrophil activation and chemotaxis.,PTM:Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis.,subunit:Binds actin.,tissue specificity:Activated T-lymphocytes., |
