Name: MACC1 Polyclonal Antibody
SKU: WP15358
Price: 268 USD
Availability: InStock

MACC1 Polyclonal Antibody

Ucallm_WP15358-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15358-100

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Product details

Background:

MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],

Specifications

Size	50μL/100μL
Target	MACC1
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	97kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460
Specificity	MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.
Gene Name	MACC1
Protein Name	Metastasis-associated in colon cancer protein 1
Other Name	MACC1; / Metastasis-associated in colon cancer protein 1; / SH3 domain-containing protein 7a5
Species	Human
Gene ID	346389
Uniprot	Q6ZN28
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors.
Tissue Expression	Preferentially expressed in metastasizing tumors.
Signaling_pathway
Research Areas
Function	Function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors.,