mAChR M4 Polyclonal Antibody
Ucallm_WP13045-50
Price range: $268.00 through $328.00
Product details
Background:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | mAChR M4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHRM4. AA range:236-285 |
| Specificity | mAChR M4 Polyclonal Antibody detects endogenous levels of mAChR M4 protein. |
| Gene Name | CHRM4 |
| Protein Name | Muscarinic acetylcholine receptor M4 |
| Other Name | CHRM4; / Muscarinic acetylcholine receptor M4 |
| Species | Human |
| Gene ID | 1132 |
| Uniprot | P08173, |
| Species.1 | Mouse |
| Gene ID.1 | 12672 |
| Uniprot.1 | P32211, |
| Species.2 | Rat |
| Gene ID.2 | 25111 |
| Uniprot.2 | P08485 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Brain, |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Nervous system >> Cholinergic synapse |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Cholinergic synapse; / >>Regulation of actin cytoskeleton |
| Function | Function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family., |
Please login to post questions
Related products
