SKU: WP13046 Categories: ,

mAChR M5 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP13046-100
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Product details

Background:

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetmAChR M5
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)60kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CHRM5. AA range:281-330
SpecificitymAChR M5 Polyclonal Antibody detects endogenous levels of mAChR M5 protein.
Gene NameCHRM5
Protein NameMuscarinic acetylcholine receptor M5
Other NameCHRM5; / Muscarinic acetylcholine receptor M5
SpeciesHuman
Gene ID1133
UniprotP08912,
Species.1Mouse
Gene ID.1
Uniprot.1Q920H4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue ExpressionBrain,Keratinocyte,Lens epithelium,Placenta,Testis,
Signaling_pathwayCellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Nervous system >> Cholinergic synapse;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Research Areas>>Calcium signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Cholinergic synapse; / >>Regulation of actin cytoskeleton; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases
FunctionFunction:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,
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