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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/MAPK Organizer 1 Polyclonal Antibody
SKU: WP15476 Categories: ,

MAPK Organizer 1 Polyclonal Antibody

Ucallm_WP15476-50

Price range: $268.00 through $328.00

SKU: WP15476-100
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Product details

Background:

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Specifications

Size50μL/100μL
TargetMAPK Organizer 1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)34kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human WDR83. AA range:141-190
SpecificityMAPK Organizer 1 Polyclonal Antibody detects endogenous levels of MAPK Organizer 1 protein.
Gene NameWDR83
Protein NameWD repeat domain-containing protein 83
Other NameWDR83; / MORG1; / WD repeat domain-containing protein 83; / Mitogen-activated protein kinase organizer 1; / MAPK organizer 1
SpeciesHuman
Gene ID84292
UniprotQ9BRX9,
Species.1Mouse
Gene ID.167836
Uniprot.1Q9DAJ4,
Species.2Rat
Gene ID.2288924
Uniprot.2Q5BLX8
Cellular LocalizationCytoplasm . Nucleus . Predominantly cytoplasmic. Partially nuclear. .
Tissue ExpressionKidney proximal tubule,Muscle,
Signaling_pathway
Research Areas
FunctionFunction:Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.,similarity:Belongs to the WD repeat MORG1 family.,similarity:Contains 7 WD repeats.,subcellular location:Predominantly cytoplasmic (By similarity). Partially nuclear.,subunit:Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, MAP2K1IP1/MP1, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.,
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