MCLN2 rabbit pAb
Ucallm_WP3542-50
Price range: $268.00 through $328.00
Product details
Background:
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009],
Specifications
| Size | 50μL/100μL |
| Target | MCLN2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MCLN2 AA range: 328-378 |
| Specificity | This antibody detects endogenous levels of MCLN2 at Human/Mouse |
| Gene Name | MCOLN2 |
| Protein Name | MCLN2 |
| Other Name | Mucolipin-2 |
| Species | Human |
| Gene ID | 255231 |
| Uniprot | Q8IZK6, |
| Species.1 | Mouse |
| Gene ID.1 | 68279 |
| Uniprot.1 | Q8K595 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Late endosome membrane; Multi-pass membrane protein . Lysosome membrane; Multi-pass membrane protein . Recycling endosome membrane; Multi-pass membrane protein . Localizes to recycling endosomes in activated macrophages and microglia. . |
| Tissue Expression | Uterus, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Calcium signaling pathway |
| Function | sequence Caution:Translated as Trp.,similarity:Belongs to the transient receptor family. Polycystin subfamily., |
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