MDHC Polyclonal Antibody
Ucallm_WP3373-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq,
Specifications
| Size | 50μL/100μL |
| Target | MDHC |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MDHC Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MDH1 MDHA |
| Protein Name | Malate dehydrogenase, cytoplasmic (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC 1.1.1.96) |
| Other Name | |
| Species | Human |
| Gene ID | 4190 |
| Uniprot | P40925, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P14152, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O88989 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Brain,Cajal-Retzius cell,Heart,Placenta,T-cell, |
| Signaling_pathway | |
| Research Areas | >>Citrate cycle (TCA cycle); / >>Cysteine and methionine metabolism; / >>Pyruvate metabolism; / >>Glyoxylate and dicarboxylate metabolism; / >>Metabolic pathways; / >>Carbon metabolism; / >>Proximal tubule bicarbonate reclamation |
| Function | Catalytic activity:(S)-malate + NAD(+) = oxaloacetate + NADH.,online information:Malate dehydrogenase entry,similarity:Belongs to the LDH/MDH superfamily. MDH type 2 family.,subunit:Homodimer., |
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