Price range: $268.00 through $328.00
Background:
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012],
| Size | 50μL/100μL |
| Target | MEX3B |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MEX3B AA range: 434-484 |
| Specificity | This antibody detects endogenous levels of MEX3B at Human/Mouse |
| Gene Name | MEX3B KIAA2009 RKHD3 RNF195 |
| Protein Name | MEX3B |
| Other Name | RNA-binding protein MEX3B; / RING finger and KH domain-containing protein 3; / RING finger protein 195 |
| Species | Human |
| Gene ID | 84206 |
| Uniprot | Q6ZN04, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q69Z36 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Cytoplasm, P-body . Cytoplasmic granule . Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3. |
| Tissue Expression | Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:Binds RNA through its KH domains.,Function:RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.,PTM:Phosphorylated.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 KH domains.,subcellular location:Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.,tissue specificity:Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level., |
