Product details
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MEX3C rabbit pAb
Ucallm_WP6991-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MEX3C |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 72kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MEX3C |
| Specificity | This antibody detects endogenous levels of MEX3C at Human, Mouse |
| Gene Name | MEX3C RKHD2 RNF194 BM-013 |
| Protein Name | RNA-binding E3 ubiquitin-protein ligase MEX3C (RING finger and KH domain-containing protein 2) (RING finger protein 194) |
| Other Name | |
| Species | Human |
| Gene ID | 51320 |
| Uniprot | Q5U5Q3, |
| Species.1 | Mouse |
| Gene ID.1 | 240396 |
| Uniprot.1 | Q05A36 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation. |
| Tissue Expression | Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine. |
| Signaling_pathway | |
| Research Areas | |
| Function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. |
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