MICU1 Monoclonal Antibody [Mix]
Ucallm_WM1137-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013],
Specifications
| Size | 50μL/100μL |
| Target | MICU1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IHC |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; IHC 1:100-200; IF 1:200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 4H3 |
| Immunogen | Recombinant Protein of MICU1 |
| Specificity | The antibody detects endogenous MICU1 protein. |
| Gene Name | MICU1 |
| Protein Name | Calcium uptake protein 1, mitochondrial |
| Other Name | Calcium uptake protein 1, mitochondrial; / Atopy-related autoantigen CALC; / ara CALC; / Calcium-binding atopy-related autoantigen 1; / allergen Hom s 4 |
| Species | Human |
| Gene ID | 10367 |
| Uniprot | Q9BPX6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8VCX5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q6P6Q9 |
| Cellular Localization | Mitochondrion inner membrane; Single-pass membrane protein . Mitochondrion intermembrane space . |
| Tissue Expression | Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | allergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.,Function:Induces T helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.,sequence Caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 2 EF-hand domains.,tissue specificity:Expressed in epithelial cell line. Strongly expressed in epidermal keratinocytes and dermal endothelial cells., |
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