SKU: WP0994 Categories: ,

MPRD Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP0994-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011],

Specifications

Size50μL/100μL
TargetMPRD
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)30kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityMPRD Polyclonal Antibody detects endogenous levels of protein.
Gene NameM6PR MPR46 MPRD
Protein NameCation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)
Other Name
SpeciesHuman
Gene ID4074
UniprotP20645,
Species.1Mouse
Gene ID.1
Uniprot.1P24668,
Species.2Rat
Gene ID.2
Uniprot.2Q6AY20
Cellular LocalizationLysosome membrane; Single-pass type I membrane protein.
Tissue ExpressionLeukocyte,Liver,Muscle,Uterus,
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Lysosome
Research Areas>>Lysosome; / >>Phagosome; / >>Salmonella infection
FunctionDomain:The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.,Function:Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.,miscellaneous:This receptor has optimal binding in the presence of divalent cations.,subunit:Homodimer. Binds GGA1, GGA2 and GGA3.,
Please login to post questions
Back to Top
Product has been added to your cart