Name: NAC-1 Monoclonal Antibody
SKU: WM0334
Price: 268 USD
Availability: InStock

NAC-1 Monoclonal Antibody

Ucallm_WM0334-50

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WM0334-50

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Product details

Background:
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012],

Specifications

Size	50μL/100μL
Target	NAC-1
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	57kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	10H4
Immunogen	Purified recombinant fragment of human NAC-1 expressed in E. Coli.
Specificity	NAC-1 Monoclonal Antibody detects endogenous levels of NAC-1 protein.
Gene Name	BTB14
Protein Name	Nucleus accumbens-associated protein
Other Name	NACC1; / BTBD14B; / NAC1; / Nucleus accumbens-associated protein 1; / NAC-1; / BTB/POZ domain-containing protein 14B
Species	Human
Gene ID	112939
Uniprot	Q96RE7,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q7TSZ8
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation. .
Tissue Expression	Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
Signaling_pathway
Research Areas
Function	Function:Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.,similarity:Contains 1 BTB (POZ) domain.,subcellular location:Distribution in the cytoplasm is dependent on phosphorylation.,subunit:Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1.,tissue specificity:Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.,