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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/PRK2 Monoclonal Antibody
SKU: WM0382 Categories: ,

PRK2 Monoclonal Antibody

Ucallm_WM0382-50

Price range: $268.00 through $328.00

SKU: WM0382-50
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Product details

Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein., domain:The C1 domain does not bind the diacylglycerol (DAG)., enzyme regulation:Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain) and Thr-958 (turn motif), need to be phosphorylated for its full activation., function:Exhibits a preference for highly basic protein substrates., PTM:Activated by limited proteolysis with trypsin., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 C2 domain., similarity:Contains 1 protein kinase domain., similarity:Contains 3 REM (Hr1) repeats.,

Specifications

Size50μL/100μL
TargetPRK2
ReactivityHuman, Mouse, Rat, Monkey
ApplicationsWB, IHC, IF, FC, ELISA
MW(Calculated)112kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number4C2
ImmunogenPurified recombinant fragment of human PRK2 expressed in E. Coli.
SpecificityPRK2 Monoclonal Antibody detects endogenous levels of PRK2 protein.
Gene NamePKN2
Protein NameSerine/threonine-protein kinase N2
Other NamePKN2; / PRK2; / PRKCL2; / Serine/threonine-protein kinase N2; / PKN gamma; / Protein kinase C-like 2; / Protein-kinase C-related kinase 2
SpeciesHuman
Gene ID5586
UniprotQ16513,
Species.1Mouse
Gene ID.1109333
Uniprot.1Q8BWW9,
Species.2Rat
Gene ID.2
Uniprot.2O08874
Cellular LocalizationCytoplasm . Nucleus . Membrane . Cell projection, lamellipodium . Cytoplasm, cytoskeleton . Cleavage furrow . Midbody . Cell junction . Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. .
Tissue ExpressionUbiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells.
Signaling_pathwayOrganismal Systems >> Immune system >> NOD-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas>>PI3K-Akt signaling pathway; / >>NOD-like receptor signaling pathway; / >>Yersinia infection
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Domain:The C1 domain does not bind the diacylglycerol (DAG).,enzyme regulation:Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain) and Thr-958 (turn motif), need to be phosphorylated for its full activation.,Function:Exhibits a preference for highly basic protein substrates.,PTM:Activated by limited proteolysis with trypsin.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 REM (Hr1) repeats.,
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