Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Rak |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 58kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 15B5 |
| Immunogen | Purified recombinant fragment of Rak (aa2-300) expressed in E. Coli. |
| Specificity | Rak Monoclonal Antibody detects endogenous levels of Rak protein. |
| Gene Name | FRK |
| Protein Name | Tyrosine-protein kinase FRK |
| Other Name | FRK; / PTK5; / RAK; / Tyrosine-protein kinase FRK; / FYN-related kinase; / Nuclear tyrosine protein kinase RAK; / Protein-tyrosine kinase 5 |
| Species | Human |
| Gene ID | 2444 |
| Uniprot | P42685, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q922K9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Predominantly found in the nucleus, with a small fraction found in the cell periphery. |
| Tissue Expression | Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Restricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin., |
