RBM15B rabbit pAb
Ucallm_WP6438-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | RBM15B |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 98kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RBM15B |
| Specificity | This antibody detects endogenous levels of RBM15B at Human, Mouse |
| Gene Name | RBM15B OTT3 |
| Protein Name | Putative RNA-binding protein 15B (One-twenty two protein 3) (HuOTT3) (RNA-binding motif protein 15B) |
| Other Name | |
| Species | Human |
| Gene ID | 29890 |
| Uniprot | Q8NDT2, |
| Species.1 | Mouse |
| Gene ID.1 | 109095 |
| Uniprot.1 | Q6PHZ5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleoplasm . Nucleus speckle . Nucleus envelope . Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA . Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex . Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist . Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation . Inhibits pre-mRNA splicing . Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 . |
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