Recombinant CD31 Fc-Fused Nanobody (VF0623)
Ucallm_WN0272
$365.00
Product details
Background:The protein encoded byThis gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Specifications
| Size | 100μL |
| Target | CD31 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0098 |
| Immunogen | Purified recombinant Human CD31 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD31 protein. |
| Gene Name | PECAM1 |
| Protein Name | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) |
| Other Name | Adhesion molecule antibody; / CD31 antibody; / CD31 antigen antibody; / CD31 EndoCAM antibody; / EndoCAM antibody; / FLJ34100 antibody; / FLJ58394 antibody; / GPIIA antibody; / GPIIA' antibody; / PECA1 antibody; / PECA1_HUMAN antibody; / Pecam 1 antibody; / PECAM 1 CD31 EndoCAM antibody; / PECAM antibody; / PECAM-1 antibody; / Pecam1 antibody; / Platelet and endothelial cell adhesion molecule 1 antibody; / Platelet endothelial cell adhesion molecule antibody; / Platelet/endothelial cell adhesion molecule 1 antibody; / CD31 nanobody |
| Species | Human |
| Gene ID | 5175 |
| Uniprot | P16284 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. .; [Isoform Long]: Cell membrane; Single-pass type I membrane protein . Membrane raft . Cell junction . Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. .; [Isoform Delta15]: Cell junction . Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. |
| Tissue Expression | Expressed in professional APCs: macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:1532254, PubMed:23783831). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831). |
| Signaling_pathway | Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.,online information:CD31 entry,online information:PECAM-1,online information:The Singapore human mutation and polymorphism database,PTM:Phosphorylated on Ser and Tyr residues after cellular activation.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart., |
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