Recombinant CD32 Fc-Fused Nanobody (VF0206)
Ucallm_WN0289
$365.00
Product details
Background:The Fc fragment of IgG receptor IIb encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations inThis gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found forThis gene.
Specifications
| Size | 100μL |
| Target | CD32 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0492 |
| Immunogen | Purified recombinant Human CD32 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD32 protein. |
| Gene Name | FCGR2B |
| Protein Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
| Other Name | CD32 antibody; / CD32 antigen antibody; / CD32B antibody; / CDw32 antibody; / Fc fragment of IgG; / low affinity II; / receptor for; / CD32; / antibody; / Fc fragment of IgG; / low affinity IIb; / receptor antibody; / Fc fragment of IgG; / low affinity IIb; / receptor; / CD32; / antibody; / Fc fragment of IgG; / low affinity IIb; / receptor for; / CD32; / antibody; / Fc fragment of IgG; / low affinity IIb; / receptor for antibody; / Fc gamma receptor IIB antibody; / Fc gamma RII antibody; / Fc gamma RIIB antibody; / Fc-gamma RII antibody; / Fc-gamma RII-b antibody; / Fc-gamma-RIIb antibody; / FCG2 antibody; / FCG2B_HUMAN antibody; / Fcgr2 antibody; / FCGR2B antibody; / FCRII antibody; / FcRII-b antibody; / IGFR2 antibody; / IgG Fc receptor II beta antibody; / IgG Fc receptor II-b antibody; / Low affinity immunoglobulin gamma Fc region receptor II antibody; / Low affinity immunoglobulin gamma Fc region receptor II-b antibody; / Ly-17 antibody; / Lym 1 antibody; / Lymphocyte antigen 17 antibody; / CD32 nanobody |
| Species | Human |
| Gene ID | 2213 |
| Uniprot | P31994 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Tissue Expression | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation |
| Research Areas | |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
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