Name: Recombinant HLA-DRA Fc-Fused Nanobody (VF0157)
SKU: WN0605
Price: 365 USD
Availability: InStock

Product details

Background:HLA-DRA is one of the HLA class II alpha chain paralogues.This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

Specifications

Size	100μL
Target	HLA-DRA
Reactivity	Human
Applications	ELISA
MW(Calculated)
MW(Observed)
Host Species
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:5000-100000
Formulation	Phosphate-buffered solution
Purification	Recombinant Expression and Affinity purified
Storage	-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration	Please check the information on the tube
Clonality
Clone Number	VF0321
Immunogen	Purified recombinant Human HLA-DRA
Specificity	This recombinant monoclonal antibody can detects endogenous levels of HLA-DRA protein.
Gene Name	HLA-DRA HLA-DRA1
Protein Name	HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
Other Name	DASS-397D15.1 antibody; / DR alpha chain antibody; / DR alpha chain precursor antibody; / DRA_HUMAN antibody; / DRB1 antibody; / DRB4 antibody; / FLJ51114 antibody; / Histocompatibility antigen HLA DR alpha antibody; / Histocompatibility antigen HLA-DR alpha antibody; / HLA class II histocompatibility antigen antibody; / HLA class II histocompatibility antigen DR alpha chain antibody; / HLA DR1B antibody; / HLA DR3B antibody; / HLA DRA antibody; / HLA DRA1 antibody; / HLA DRB1 antibody; / HLA DRB3 antibody; / HLA DRB4 antibody; / HLA DRB5 antibody; / HLA-DR histocompatibility type antibody; / HLA-DRA antibody; / HLADR4B antibody; / HLADRA1 antibody; / HLADRB antibody; / Major histocompatibility complex class II DR alpha antibody; / Major histocompatibility complex class II DR beta 1 antibody; / Major histocompatibility complex class II DR beta 3 antibody; / Major histocompatibility complex class II DR beta 4 antibody; / Major histocompatibility complex class II DR beta 5 antibody; / MGC117330 antibody; / MHC cell surface glycoprotein antibody; / MHC class II antigen DRA antibody; / MHC II antibody; / MLRW antibody; / OTTHUMP00000029406 antibody; / OTTHUMP00000029407 antibody; / HLA-DRA nanobody
Species	Human
Gene ID	3122
Uniprot	P01903
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Endoplasmic reticulum membrane; Single-pass type I membrane protein . Early endosome membrane; Single-pass type I membrane protein . Late endosome membrane; Single-pass type I membrane protein . Lysosome membrane; Single-pass type I membrane protein . Autolysosome membrane; Single-pass type I membrane protein. The MHCII complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:9075930, PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:15322540, PubMed:29884618). .
Tissue Expression	Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Human Diseases >> Immune disease >> Asthma;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Allograft rejection;Human Diseases >> Immune disease >> Graft-versus-host disease;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas
Function	Disease:Genetic variations in HLA-DRA are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,polymorphism:The following alleles of DRA are known: DRA0101 and DRA0102. The sequence shown is that of DRA*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain.,