Price range: $268.00 through $328.00
Background:
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016],
| Size | 50μL/100μL |
| Target | REV1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 137kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | REV1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | REV1 REV1L |
| Protein Name | DNA repair protein REV1 (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase) |
| Other Name | |
| Species | Human |
| Gene ID | 51455 |
| Uniprot | Q9UBZ9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q920Q2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | >>Fanconi anemia pathway |
| Function | Domain:The C-terminal domain is necessary for protein interactions.,Function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.,similarity:Belongs to the DNA polymerase type-Y family.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 umuC domain.,subunit:Monomer. Binds MAD2L2, POLH, POLI, POLK and REV3L. May bind ITGA3.,tissue specificity:Ubiquitous., |
