RGRF1 Polyclonal Antibody
Ucallm_WP3399-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009],
Specifications
| Size | 50μL/100μL |
| Target | Ras-GRF1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 140kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | RGRF1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RASGRF1 CDC25 GNRP GRF1 |
| Protein Name | Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) |
| Other Name | RASGRF1; / CDC25; / GNRP; / GRF1; / Ras-specific guanine nucleotide-releasing factor 1; / Ras-GRF1; / Guanine nucleotide-releasing protein; / GNRP; / Ras-specific nucleotide exchange factor CDC25 |
| Species | Human |
| Gene ID | 5923 |
| Uniprot | Q13972, |
| Species.1 | Mouse |
| Gene ID.1 | 19417 |
| Uniprot.1 | P27671, |
| Species.2 | Rat |
| Gene ID.2 | 192213 |
| Uniprot.2 | P28818 |
| Cellular Localization | intracellular,cytosol,plasma membrane,growth cone,neuron projection, |
| Tissue Expression | Brain,Thalamus, |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Focal adhesion |
| Function | Domain:The DH (DBL-homology) domain mediates interaction with RASGRF2.,Function:Promotes the exchange of Ras-bound GDP by GTP.,PTM:Ubiquitinated.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 IQ domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 PH domains.,subunit:Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability., |
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