RNF126 rabbit pAb
Ucallm_WP8954-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | RNF126 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 34kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RNF126 |
| Specificity | This antibody detects endogenous levels of RNF126 at Human, Mouse |
| Gene Name | RNF126 |
| Protein Name | RING finger protein 126 |
| Other Name | |
| Species | Human |
| Gene ID | 55658 |
| Uniprot | Q9BV68, |
| Species.1 | Mouse |
| Gene ID.1 | 70294 |
| Uniprot.1 | Q91YL2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Highly expressed in liver and testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins . Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome . May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor . May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination . By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation . May monoubiquitinate AICDA . |
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