Product details
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RPUSD4 rabbit pAb
Ucallm_WP8593-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RPUSD4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 41kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RPUSD4 |
| Specificity | This antibody detects endogenous levels of RPUSD4 at Human, Mouse,Rat |
| Gene Name | RPUSD4 |
| Protein Name | RNA pseudouridylate synthase domain-containing protein 4 |
| Other Name | |
| Species | Human |
| Gene ID | 84881 |
| Uniprot | Q96CM3, |
| Species.1 | Mouse |
| Gene ID.1 | 71989 |
| Uniprot.1 | Q9CWX4, |
| Species.2 | Rat |
| Gene ID.2 | 315550 |
| Uniprot.2 | Q4QQT0 |
| Cellular Localization | Mitochondrion matrix . Nucleus . Cytoplasm . Mainly localizes to mitochondrion (PubMed:23435261, PubMed:27974379, PubMed:28082677). Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:27974379, PubMed:28082677). Also found in nucleus and cytoplasm (PubMed:23435261). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates . Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) . This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation . Acts on position 39 in mitochondrial tRNA(Phe) . Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions . Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing . |
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