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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Rsk-1 Monoclonal Antibody
SKU: WM0405 Categories: ,

Rsk-1 Monoclonal Antibody

Ucallm_WM0405-50

Price range: $268.00 through $328.00

SKU: WM0405-50
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Product details

Background:
ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetRsk-1
ReactivityHuman
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)83kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number5D7
ImmunogenPurified recombinant fragment of human Rsk-1 expressed in E. Coli.
SpecificityRsk-1 Monoclonal Antibody detects endogenous levels of Rsk-1 protein.
Gene NameRPS6KA1 MAPKAPK1A RSK1
Protein NameRibosomal protein S6 kinase alpha-1
Other NameRPS6KA1; / MAPKAPK1A; / RSK1; / Ribosomal protein S6 kinase alpha-1; / S6K-alpha-1; / 90 kDa ribosomal protein S6 kinase 1; / p90-RSK 1; / p90RSK1; / p90S6K; / MAP kinase-activated protein kinase 1a; / MAPK-activated protein kinase 1a; / MAPKAP kinase 1a; / MAPKAP
SpeciesHuman
Gene ID6195
UniprotQ15418
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus. Cytoplasm.
Tissue ExpressionColon,Epithelium,
Signaling_pathwayOrganismal Systems >> Nervous system >> Neurotrophin signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas>>MAPK signaling pathway; / >>Oocyte meiosis; / >>mTOR signaling pathway; / >>Thermogenesis; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Progesterone-mediated oocyte maturation; / >>Insulin resistance; / >>Yersinia infection; / >>Chemical carcinogenesis - receptor activation
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,
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