Rsk-1 Monoclonal Antibody
Ucallm_WM0405-50
Price range: $268.00 through $328.00
Product details
Background:
ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Rsk-1 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 83kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 5D7 |
| Immunogen | Purified recombinant fragment of human Rsk-1 expressed in E. Coli. |
| Specificity | Rsk-1 Monoclonal Antibody detects endogenous levels of Rsk-1 protein. |
| Gene Name | RPS6KA1 MAPKAPK1A RSK1 |
| Protein Name | Ribosomal protein S6 kinase alpha-1 |
| Other Name | RPS6KA1; / MAPKAPK1A; / RSK1; / Ribosomal protein S6 kinase alpha-1; / S6K-alpha-1; / 90 kDa ribosomal protein S6 kinase 1; / p90-RSK 1; / p90RSK1; / p90S6K; / MAP kinase-activated protein kinase 1a; / MAPK-activated protein kinase 1a; / MAPKAP kinase 1a; / MAPKAP |
| Species | Human |
| Gene ID | 6195 |
| Uniprot | Q15418 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Cytoplasm. |
| Tissue Expression | Colon,Epithelium, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Oocyte meiosis; / >>mTOR signaling pathway; / >>Thermogenesis; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Progesterone-mediated oocyte maturation; / >>Insulin resistance; / >>Yersinia infection; / >>Chemical carcinogenesis - receptor activation |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation., |
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