Product details
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RTEL1 rabbit pAb
Ucallm_WP7413-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RTEL1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 134kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RTEL1 |
| Specificity | This antibody detects endogenous levels of RTEL1 at Human, Mouse,Rat |
| Gene Name | RTEL1 C20orf41 KIAA1088 NHL |
| Protein Name | Regulator of telomere elongation helicase 1 (Novel helicase-like) |
| Other Name | |
| Species | Human |
| Gene ID | 51750 |
| Uniprot | Q9NZ71, |
| Species.1 | Mouse |
| Gene ID.1 | 269400 |
| Uniprot.1 | Q0VGM9, |
| Species.2 | Rat |
| Gene ID.2 | 362288 |
| Uniprot.2 | Q5RJZ1 |
| Cellular Localization | Nucleus . Colocalizes with PCNA within the replication foci in S-phase cells. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. |
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