SKU: WP14388 Categories: ,

S-100A10 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14388-100
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Product details

Background:

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetS-100A10
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)11kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human S-100A10. AA range:3-52
SpecificityS-100A10 Polyclonal Antibody detects endogenous levels of S-100A10 protein.
Gene NameS100A10
Protein NameProtein S100-A10
Other NameS100A10; / ANX2LG; / CAL1L; / CLP11; / Protein S100-A10; / Calpactin I light chain; / Calpactin-1 light chain; / Cellular ligand of annexin II; / S100 calcium-binding protein A10; / p10 protein; / p11
SpeciesHuman
Gene ID6281
UniprotP60903,
Species.1Mouse
Gene ID.120194
Uniprot.1P08207,
Species.2Rat
Gene ID.281778
Uniprot.2P05943
Cellular Localizationintegral component of membrane,extrinsic component of plasma membrane,membrane raft,extracellular exosome,
Tissue ExpressionBrain,Keratinocyte,
Signaling_pathway
Research Areas>>Salmonella infection
FunctionFunction:Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.,miscellaneous:Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.,similarity:Belongs to the S-100 family.,subunit:Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A.,
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