S-100A3 Polyclonal Antibody
Ucallm_WP14390-50
Price range: $268.00 through $328.00
Product details
Background:
S100 calcium binding protein A3(S100A3) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | S-100A3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 12kD |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human S100A3. AA range:26-75 |
| Specificity | S-100A3 Polyclonal Antibody detects endogenous levels of S-100A3 protein. |
| Gene Name | S100A3 |
| Protein Name | Protein S100-A3 |
| Other Name | S100A3; / S100E; / Protein S100-A3; / Protein S-100E; / S100 calcium-binding protein A3 |
| Species | Human |
| Gene ID | 6274 |
| Uniprot | P33764, |
| Species.1 | Mouse |
| Gene ID.1 | 20197 |
| Uniprot.1 | P62818, |
| Species.2 | Rat |
| Gene ID.2 | 114216 |
| Uniprot.2 | P62819 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Skin specific, specifically expressed at the inner endocuticle of hair fibers. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Binds both calcium and zinc. Probably binds 2 zinc ions per molecule. May be involved in calcium-dependent cuticle cell differentiation and hair shaft formation.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer.,tissue specificity:Skin specific., |
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