SKU: WP17714 Categories: ,

S-100A6 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP17714-100
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Product details

Background:

S100 calcium binding protein A6(S100A6) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetS100A6
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)10kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human S-100A6 AA range: 21-70
SpecificityThis antibody detects endogenous levels of Human S-100A6
Gene NameS100A6 CACY
Protein NameS100A6
Other NameProtein S100-A6; / Calcyclin; / Growth factor-inducible protein 2A9; / MLN 4; / Prolactin receptor-associated protein; / PRA; / S100 calcium-binding protein A6
SpeciesHuman
Gene ID6277
UniprotP06703,
Species.1Mouse
Gene ID.120200
Uniprot.1P14069,
Species.2Rat
Gene ID.285247
Uniprot.2P05964
Cellular LocalizationNucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Expression
Signaling_pathway
Research Areas
Functioninduction:Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.,miscellaneous:This protein co-purified with the prolactin receptor.,PTM:The N-terminus is blocked.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer, antiparallel. Interacts with SUGT1.,
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