Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is an inositol 1, 4, 5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4, 5-bisphosphate and phosphatidylinositol 3, 4, 5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],
| Size | 50μL/100μL |
| Target | SAC2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 125kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SAC2 AA range: 1006-1056 |
| Specificity | This antibody detects endogenous levels of SAC2 at Human/Mouse |
| Gene Name | INPP5F KIAA0966 SAC2 MSTP007 MSTP047 |
| Protein Name | SAC2 |
| Other Name | |
| Species | Human |
| Gene ID | 22876 |
| Uniprot | Q9Y2H2, |
| Species.1 | Mouse |
| Gene ID.1 | 101490 |
| Uniprot.1 | Q8CDA1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes. . |
| Tissue Expression | Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). |
| Signaling_pathway | |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Phosphatidylinositol signaling system |
| Function | Function:Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.,miscellaneous:Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.,similarity:Contains 1 SAC domain.,tissue specificity:Ubiquitous., |
