Price range: $268.00 through $328.00
Background:
This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
| Size | 50μL/100μL |
| Target | Snrp116 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 109kD |
| MW(Observed) | 120kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1188 |
| Immunogen | Synthesized peptide derived from human EFTUD2. AA range:300-400 |
| Specificity | This antibody detects endogenous levels of Snrp116. |
| Gene Name | EFTUD2 |
| Protein Name | 116 kDa U5 small nuclear ribonucleoprotein component |
| Other Name | EFTUD2; / KIAA0031; / SNRP116; / 116 kDa U5 small nuclear ribonucleoprotein component; / Elongation factor Tu GTP-binding domain-containing protein 2; / SNU114 homolog; / hSNU114; / U5 snRNP-specific protein; / 116 kDa; / U5-116 kDa |
| Species | Human |
| Gene ID | 9343 |
| Uniprot | Q15029, |
| Species.1 | Mouse |
| Gene ID.1 | 20624 |
| Uniprot.1 | O08810 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nuclear |
| Tissue Expression | Bone marrow,Epithelium,Muscle,Thalamus,Uterus, |
| Signaling_pathway | |
| Research Areas | >>Spliceosome |
| Function | Function:Component of the U5 snRNP complex required for pre-mRNA splicing.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Binds GTP. Interacts with PRPF8., |
