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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/SOCS5 Polyclonal Antibody
SKU: WP1794 Categories: ,

SOCS5 Polyclonal Antibody

Ucallm_WP1794-50

Price range: $268.00 through $328.00

SKU: WP1794-100
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Product details

Background:

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetSOCS5
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)58kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificitySOCS5 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSOCS5 CIS6 CISH5 CISH6 KIAA0671
Protein NameSuppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)
Other Name
SpeciesHuman
Gene ID9655
UniprotO75159,
Species.1Mouse
Gene ID.1
Uniprot.1O54928
Species.2
Gene ID.2
Uniprot.2
Cellular Localizationcytoplasm,
Tissue ExpressionBrain,Placenta,Testis,Thalamus,
Signaling_pathwayOrganismal Systems >> Endocrine system >> Prolactin signaling pathway;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Research Areas>>JAK-STAT signaling pathway; / >>Prolactin signaling pathway
FunctionDomain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,Function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 is involved in regulating T-helper cell differentiation by inhibition of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling (By similarity). May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,subunit:Interacts, via the first 50 AA, with IL4RA (through a box 1-containing cytpolasmic domain) and inhibits IL4 signaling.,
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